Introduction to BKL Tools for Functional Analysis

BKL Functional Analysis Tools comprise powerful specialized tools for analyzing customized lists of genes using BKL annotation, visualizing pathways and building networks. Brief descriptions of the BKL Functional Analysis Tools are provided below, with hyperlinks to detailed information. A view of the interface used to access BKL Functional Analysis Tools is shown in the figure below.

Functional Analysis Tool Menu

View pathways and build networks

Use the PathFinder visualization tool to view canonical signaling and metabolic pathways and to build custom protein-protein interaction and gene regulation networks based on the curated data made available in the BKL.

Learn more about the PathFinder.

Identify shared attributes

Use the Functional Analysis tool to analyze a list of genes or miRNAs for the presence of statistically over-represented, curated attributes. The output is a list of curated attributes spanning up to eight different topics including GO molecular function, GO biological process, associated diseases, canonical pathways and more.

Learn more about the Functional Analysis tool.

Please note: The Functional Analysis tool is available, both, by subscription to the PROTEOME as well as by subscription the TRANSFAC module, but for some species the number of genes included in TRANSFAC may be less than the number of genes included in PROTEOME.

Identify shared networks

Use the Network Analysis tool to analyze a list of genes for the presence of network clusters. The output is a list of protein interaction networks based on BKL curated data. These networks can be visualized, further edited and exported for publication via the linked BKL Pathfinder tool.

Learn more about the Network Analysis tool.

Please note: The Network Analysis tool is only available by subscription to the PROTEOME module.

Predict protein attributes

Use the BioKnowledge Transfer tool to assign predictive functions to submitted protein sequences based on domain structure and sequence similarity to more than 200,000 proteins spanning more than 20 species.

Learn more about the BioKnowledge Transfer tool.