| First Level
Classification (Based on Transcription Factor Binding Site
Combination) |
Explanation |
Second Level
Classification |
|
Inducible/constitutive |
Composite elements formed by binding sites comprising
inducible and constitutively expressed transcription factors
provide additional features of inducible regulation |
Acute phase
response |
| Cholesterol level
response |
| Epidermal growth factor
(EGF) response in keratinocytes |
| Estrogen response |
| Glucocorticoid
response |
| Hypoxia response |
| Interferon gamma
(IFN-gamma) response |
| Interleukin-1 beta
(IL-1beta) response |
| Immune response |
| Keratinocytes |
| Serum growth factor
response |
| Steroid hormone
response |
| Transforming growth
factor beta (TGF-beta) response |
| 12-O-tetradecanoylphorbol
13-acetate (TPA) response in keratinocytes |
| 12-O-tetradecanoylphorbol
13-acetate (TPA) response in smooth muscle cells |
| Viral infection
response |
|
Inducible/inducible |
Composite elements formed by binding sites comprising
inducible transcription factors provide cross-coupling of signal
transduction pathways |
Acute phase
response |
| Ca2+ and protein kinase C
(PKC) response |
| Ca2+ response |
| cAMP response in
kidney |
| CD28 response in
T cells |
| Estrogen response |
| Hypoxia response |
| Interferon gamma
(IFN-gamma) and tumor necrosis factor alpha (TNF-alpha)
response |
| Interferon gamma
(IFN-gamma) response |
| Interleukin-12
(IL12) response |
| Interleukin-1 beta
(IL-1beta) response |
| Interleukin-4 (IL4)
response |
| Interleukin-6 (IL6)
response |
| Immune response in T
cells |
| Late T cell
activation |
| Lipopolysaccharide (LPS)
and inflammatory cytokine response |
| Macrophages |
| Mammary gland cells |
| Non-liver cells |
| Oncogene response |
| Osteoblast-osteocyte
differentiation |
| Pituitary
gonadotropes |
|
Phorbol-12-myristate-13-acetate (PMA) response |
| Ras and fms response |
| T helper type 2 cells
(Th2) |
| Transforming growth
factor beta (TGF-beta) and hypoxia response |
| Transforming growth
factor beta (TGF-beta) response |
| Thrombin response |
| Tumor necrosis
factor alpha (TNF-alpha)
and phorbol-12-myristate-13-acetate (PMA) response |
| Tumor necrosis
factor alpha (TNF-alpha) response |
| 12-O-tetradecanoylphorbol
13-acetate (TPA) and oncogene response |
| 12-O-tetradecanoylphorbol
13-acetate (TPA)/phytohemagglutinin (PHA )response |
| Viral infection
response |
| Convergence
of transforming growth factor beta (TGF-beta) and Wnt
signalling |
|
Inducible/tissue-specific |
Composite elements formed by binding sites
comprising tissue-specific and inducible transcription factors
provide tissue-specific responses to inducing signals |
Adipocytes |
| B cells |
| Differentiating
osteoblasts |
| Hypoxia response,
endothelial cells |
| Hypoxia response, liver
and kidney cells |
| Kidney cells |
| Liver cells |
| Myeloid cells |
| Pituitary cells |
| Pituitary
gonadotropes |
| Pituitary
lactotropes |
| Pituitary
somatotropes |
| Pituitary
thyrotropes |
| Protein kinase A (PKA)
and cAMP response |
| Parathyroid hormone (PTH)
response in bone cells |
| Ras/Raf response |
| T cells |
| Transforming growth
factor beta (TGF-beta) response in B cells |
|
Tissue-specific/tissue-specific |
Composite elements formed by binding sites
comprising tissue-specific transcription factors provide some
particular aspects of tissue-specific regulation |
B cells |
| Intestine,
enterocytes |
| Liver cells |
| Muscle cells |
| Myeloid cells |
| Pancreas islet beta-cells
(insulin-producing) |
| Pituitary cells |
| Pituitary
gonadotropes |
| T cells |
|
Tissue-restricted/constitutive |
Composite elements formed by binding sites
comprising tissue-specific and constitutive transcription
factors provide additional features of the tissue-specific
transcriptional regulation |
B cells |
| endothelial cells |
| Glia cells |
| Intestine,
enterocytes |
| Liver cells |
| Lymphoid cells |
| Macrophages |
| Mammary gland cells |
| Muscle cells |
| Myeloid cells |
| Neuronal cells |
| Ovary and adrenal
cortical cells |
| Pancreas islet beta-cells
(insulin-producing) |
| Pituitary cells |
| Pituitary
lactotropes |
| Pituitary
somatotropes |
| Pituitary
thyrotropes |
| Placenta cells |
